Arsenal boss Arsene Wenger has made two alterations to the team that featured in their last league outing, with Per Mertesacker and Alexandre Lacazette making way for Francis Coquelin and Alex Iwobi as they switch to a four-man defence for the first time this season.
Pep Guardiola has decided to make two changes to the City side that started the win away to West Bromwich Albion last weekend, with Raheem Sterling and Sergio Aguero coming into the starting line-up to replace Bernardo Silva and Gabriel Jesus, respectively.
Arsenal substitutes: Macey, Debuchy, Elneny, Wilshere, Walcott, Giroud, Lacazette.
Arsenal XI (4-2-3-1): Cech; Bellerin, Koscielny, Monreal, Kolasinac; Xhaka, Coquelin; Ramsey, Ozil, Iwobi; Sanchez.
Manchester City substitutes: Bravo, Mangala, Danilo, Toure, Gundogan, Bernardo Silva, Jesus.
Manchester City XI (4-3-3): Ederson; Walker, Stones, Otamendi, Delph; De Bruyne, Fernandinho, David Silva; Sterling, Aguero, Sane.